Position: Contrast agents and biosensors for medical imaging and image-guided therapy
We are seeking a researcher focused on the development of imaging contrast agents or other biosensor approaches that are relevant to the understanding, diagnosis or treatment of disease processes. The research focus can involve imaging modalities such as MRI, PET, optical and ultrasound, and it may relate to multimodal imaging. The approaches employed should provide information related to the visualization and quantification of molecular and cellular events or aspects of the tissue microenvironment.
SRI infrastructure is housed within 250,000 square feet of research space that includes a Molecular Targeting and Therapeutics laboratory (for the design, synthesis and bioengineering of agents) as well as a large suite of research and clinical imaging instruments [one 1.5T (GE) and three 3T (GE, Philips, Siemens) research-dedicated MRI systems, a research MRI-PET system (Siemens), a system for MRI-guided focused ultrasound brain treatments (Insightec), a combined X-ray / MRI suite dedicated to research on image-guided interventions, a research CT system (Canon/Toshiba), a 7T small-bore MRI system (Bruker), a vertical 7T NMR system (Bruker), a twin multiphon laser scanning microscope (Olympus), a GE Spinlab polarizer for 13C MRI research, a wide range of ultrasound machines as well as preclinical photoacoustic systems]. This extensive imaging infrastructure is supplemented by a Device Development Lab (DDL; RF electronics and advanced machine shops), a cyclotron, flow cytometry facilities, a whole-mount 3D histopathology laboratory and GMP-grade clean rooms for drug and contrast agent development.
How To Apply: Applications should include:
1) a letter of interest of no more than 3 pages. The letter should indicate “sensors position” and briefly describe the applicant’s expertise and their fit with theCRC criteria for a Tier 2 Chair, their proposed research program and its alignment with the foci of the Physical Sciences Platform and the clinical activities in one or more of Sunnybrook’s nine research programs; in addition to the University of Toronto strategic research planand Sunnybrook’s strategic plan;
2) a complete curriculum vitae including professional services, outreach, mentoring / training of highly qualified personnel and other contributions; and
Applicants should email the letter of interest indicating “Biosensors position”, curriculum vitae, self-identification form and the names of three references to CRC@sri.utoronto.ca by February 1, 2021. Notwithstanding this deadline, applications will be considered until the positions are filled. Incomplete applications will not be considered.
The applicant must show strong evidence of research and scholarly achievement, and a proven capacity in mentoring and collaboration. The successful applicant will develop an internationally competitive research program and participate in graduate training through an academic appointment in the appropriate department at the University of Toronto (e.g. the Departments of Pharmaceutical Sciences or Medical Biophysics, or the Institute of Biomaterials and Biomedical Engineering). In addition to fostering local, national, and international collaborations, the successful applicant will be expected to collaborate with other SRI Scientists, build complementary translational research capacity, and engage with Sunnybrook Health Sciences Centre Clinicians so as to enable short- and/or long-term clinical translation of their research, ultimately contributing to Sunnybrook’s strategic direction in Personalized and Precise Treatments, with a vision of inventing the future of healthcare. SRI has an outstanding capacity for the development of translational research programs across a range of clinical foci. The applicant’s research program is thus expected to align well with one or more of the nine clinical programsdescribed below.
Holland Bone and Joint with primary foci in the areas of traumatic fracture treatment, the impact of arthritis management, and minimally invasive interventional strategies for spinal metastases;
Integrated Community that includes emergency imaging across the programs (such as trauma and cancer), has research foci in outpatient COPD, infectious diseases, and dialysis patients, and is evaluating the linkages between hospital-based resources and community healthcare providers;
Odette Cancer with Canada’s largest academic programs in breast cancer and radiation oncology, and a central nervous system program with MR-Linac and GammaKnife Technologies;
Schulich Heart with one of Canada’s largest transcutaneous structural/valve programs and its research - focused on image guided therapies for structural disease, coronary disease and complex arrhythmias - extending from device development and preclinical study to integrated care pathways creation and novel health policy;
John’s Rehab with the only organ transplant program in Canada and the sole burn and oncology programs in Ontario in addition to major programs in limb loss, MSK, cardiac, and stroke;
Tory Trauma that is the largest trauma program in Canada, with a third of the patients with traumatic brain injury and the largest burn centre in Canada;
Veterans with the largest veterans care facility in Canada; and
DAN Women and Babies Program that is home to a very high volume high risk pregnancy unit and is doing globally leading work in twin pregnancy and interventions to improve outcome of babies born preterm, as well as exploring the frontiers of in utero fetal brain imaging.
About Sunnybrook Research Institute
The Sunnybrook Research Institute (SRI) is a research organization owned by Sunnybrook Health Sciences Centre, one of Canada’s leading academic health sciences centres. SRI is fully affiliated with the University of Toronto and comprises three research platforms: Biological Sciences, Evaluative Clinical Sciences and Physical Sciences, each of which functions similarly to a university department under the leadership of a cognate director. The institute supports $100 million of annual research activities within approximately 250,000 square feet of state-of-the-art research space located at the Bayview campus of Sunnybrook. SRI has one of the best recognized and most productive research teams in the field of medical imaging and image guided therapy in the world. The Physical Sciences Platform (the platform that is recruiting a research scientist targeted by this advertisement) is comprised of 64 scientists and has a total staff of over 300, including close to 100 graduate students and postdoctoral fellows associated with the University of Toronto.