Join a Team that Lives to Improve Lives People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.
The following opportunity exists in our South San Francisco, CA headquarters:
Associate Scientist / Scientist, Biotransformation and ADME of New Modality
The department of Drug Metabolism and Pharmacokinetics (DMPK) at Genentech is seeking an Associate Scientist or Scientist with hands-on LC/MS experience and proven abilities in determining the biotransformation pathways of small molecules and other novel modalities. Primary responsibilities include:
Profiling and identifying drug metabolites in in vitro and in vivo biological matrices using HPLC with radiometric detection and LC-MS/MS
Designing, executing and reporting biotransformation studies to support drug development and regulatory filings
Designing and implementing appropriate assays and strategy to support the development of small molecules, peptides and other novel modalities
Evaluating new technologies
The DMPK group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.
PhD degree in chemistry, biochemistry, pharmaceutical sciences or other related disciplines
Hands on work in metabolite identification by LC-MS/MS and determination of biotransformation pathways of small molecules (peptides or other novel modalities is a plus)
Experience of using radiolabels, conducting regulatory filing studies, and writing scientific reports
Experience with development support of small molecules and other therapeutic modalities
Good understanding of enzyme kinetics and clearance mechanism in support of both drug discovery and development programs
Good writing and verbal communication skills
A Job with Benefits Beyond the Benefits A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
The next step is yours. To apply today, click on the "Apply online" button.
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At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.