Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
PRINCIPAL SCIENTIST, PHARMACOKINETICS, ENZYMOLOGY
Rahway, NJ Job #PHA001483
Our organization is seeking an experienced Drug Metabolism and Pharmacokinetics (DMPK) scientist for a Principal Scientist position to lead enzymology support for the Absorption, Distribution, Metabolism and Excretion (ADME) group. The successful candidate will contribute to our organization's drug discovery and clinical development efforts within the Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) in Rahway, NJ. The successful candidate will have a passion for generating high quality in vitro PPDM data for use by project teams across a range of therapeutic areas. In addition to performing assays according to standard protocols, there will be opportunities to provide enzymology expertise and develop novel methods/assays to resolve ADME issues. The successful candidate will also be involved in designing and interpreting studies utilizing in silico, in vitro or in vivo approaches to improve our success in inventing differentiated medicines. The role includes scientific supervision and mentorship of laboratory staff as well as responsibility for oversight and resource management for experimental support internally and externally. At our research division, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career with the ability to utilize cutting edge techniques such as microphysiological cell systems, humanized animal models and robotic workflows.
- Serve as an enzymology subject matter expert across functional research teams, to guide efforts in small molecule drug discovery and development. - Provide strong scientific leadership and extensive enzymology knowledge/expertise across discovery and development for program support and scientific innovation in P450 Cytochrome (CYP) and non-CYP clearance, reaction phenotyping, enzyme inhibition/induction and relevant drug-drug interaction (DDI) data generation, and delivery or conduct of quality preclinical or definitive enzymology studies in support of regulatory filings. - Expected to effectively present work at team meetings as well as promote our organization's science through publications and presentations. - Guide and develop laboratory-based scientists focused on the development and conduct of novel low- and medium-throughput in vitro assays to support discovery through regulatory filings. - Serve as a departmental resource for developing and tracking an in vitro reagent toolbox to be used for pipeline and exploratory projects.
Education Minimum Requirement:
- PhD with 8+ years or MS with 10+ years of relevant experience in the scientific field (eg drug metabolism and pharmacokinetics, pharmaceutical sciences, biochemistry, biomedical sciences).
Required Experience and Skills:
- In-depth knowledge and experience in enzymology science and technology - Strong leadership, interpersonal, problem solving, and collaboration skills along with strengths in delivering results on firm deadlines in support of discovery/early development programs. - Experience of providing ADME support to drug discovery teams and guiding the optimization of small molecule therapeutics towards development candidates. - Excellent communication skills. - Minimum of 7 years pharmaceutical and/or biotech industry experience - Experience with automation and/or robotics
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